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Should I spray Benadryl on my cat's itchy skin, sores, or hair loss?

Updated on September 23rd, 2025

Pet's info: Cat | Domestic Longhair | Male | unneutered | 9 years and 9 months old | 10 lbs

Can I spray Benadryl on my cats itching skin? He gets real bad sores and licks his hair off

2 Answers

Most Helpful Answer

Daniel Fonza, DVM

Answered By Daniel Fonza, DVM

Veterinarian

Published on October 4th, 2017

Hi there and thank you for using pet coach to address your concern. I've not had much success using topical benadryl to relieve itching in dogs or cats. I recommend using malacetic conditioning spray. You can find this online quite easily. If that does not help, I would suggest having a vet take a look at saber as there are prescription options that will help more than the spray. If you are not using a flea preventative I would consider starting this as well. Please let me know if you have any other questions or concerns.
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Related Answers from Veterinarians

  • Answered By Jessica Keay, DVM

    Veterinarian

    Published on June 22nd, 2017

    It is always recommended to discuss any new medications with your veterinarian prior to starting, as they known your pet's history and current medications best. We sometimes use benadryl in cats, but sometimes other anthistamines we prescribe such as hydroxyzine, can be more effective. Other times if the itching is intense we may need stronger medication such as a short course of steroids or a medication called apoquel (this is off label use as it is only labeled in dogs). Sometimes we also add fatty acid supplements as well because these can decrease inflammation in the skin and help with itching. I would recommend talking to your vet and letting them know her itching is bad and she needs some medication to make her more comfortable, and they can help decide the safest/best medication for your kitty.

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    1Pet Parents found this answer helpful

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