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My cat has a hot spot. Can I safely use Benadryl cream on it?

Updated on September 23rd, 2025

Is it safe to use benadryl cream on a cats hot spot?

2 Answers

Most Helpful Answer

Stacey Anstaett, DVM

Answered By Stacey Anstaett, DVM

Veterinarian

Published on December 6th, 2018

This is not likely to cause a problem, but not ideal either. Topical Benadryl is not very effective in dogs and cats, and of course cats notoriously lick off whatever you put on them. Consider using Zymox spray. You can pick it up from the local Petco. Place an e-collar (cone) on him/her for a couple of days. If the spot isn't improving after 3-4 days, have your cat evaluated by a veterinarian.
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Related Answers from Veterinarians

  • Answered By Dr. Melanie, BVSc MS

    Veterinarian

    Published on February 3rd, 2017

    No, I would not put benadryl cream on it. Although quite safe on superficial wounds, cats groom and ingest most of the topical ointment you apply and therefore should be used only under direct veterinary supervision and if there are no other appropriate options. Many human ointments contain multiple other ingredients which are not necessarily safe to be swallowed. Given that it's only a small dry spot, I wouldn't be worried about it. Keep an eye on it, and if it doesn't heal, you can take Duke into the vet to have it examined.

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