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Cat not eating on Leukeran & prednisolone for lymphoma. What to do?

Updated on September 23rd, 2025

Pet's info: Cat | Domestic Shorthair | Female | spayed | 11 years and 10 months old | 11.5 lbs

Any advice on helping kitty with appetite while on Leukeran and prednisolone for small cell lymphoma treatment? She’s already on mirtazapine and cerenia and just a few days ago she had only her 3rd Leukeran (1 every 2 wks) and it seems like her appetite has worsened. Might she begin to feel better as she gets more treatments/doses of Leukeran? Thank you

3 Answers

Most Helpful Answer

Dr. B. DVM, DACVIM (Oncology)

Answered By Dr. B. DVM, DACVIM (Oncology)

Veterinarian

Published on May 19th, 2019

Maybe and maybe not. You will need to talk to the doctor who is treating your cat as to whether or not he or she thinks that the poor appetite is due to the small cell or due to the leukeran. This drug can cause this side effect so it is important to discuss this with your doctor. If you are not seeing an oncologist your doctor can contact a local oncologist for advice on your kitty. I hope this helps and thank you for using Petco Pet Education Center, formerly Petcoach!
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Related Answers from Veterinarians

  • Answered By Ricardo Fernandez, DVM

    Veterinarian, Veterinary Oncology Resident

    Published on April 21st, 2019

    Thanks for using Petco Pet Education Center, formerly Petcoach! While in theory Leukeran can cause inappetence being a chemotherapy drug, this is rarely seen with its administration. I think the antibiotic is more likely to be cause of this issue. However, it is still possible that it was the Leukeran so it is very important you let your veterinarian know as they may consider lowering her dose next time. Most of the time when decreased appetite occurs with chemotherapy, it is because of nausea so anti-nausea medications can help a great deal. This is something your veterinarian could prescribe for her. Best of luck!

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    1Pet Parents found this answer helpful

  • Answered By Dr. B. DVM, DACVIM (Oncology)

    Veterinarian

    Published on April 18th, 2019

    It depends somewhat on the severity of her symptoms prior to treatment. Cats that minimal clinical signs and/or less aggressive disease often feel better/gain weight quicker. The steroid could help the appetite quickly as it is an appetite stimulant as well. Response to leukeran can take time, typically several doses (2 to 6 in most cases with this dosing scheme). Not every cat will respond (although the majority do) and it is important to make sure failure to respond is really a non response and not a drug related side effect (some cats do not tolerate this drug well, although most do with every 2 week dosing). Your kitty's doctor should help walk you through the process as well. I hope this helps and thank you for using Petco Pet Education Center, formerly Petcoach!

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    1Pet Parents found this answer helpful

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