This nipple was irritated by a scrape or insect bite I think, then Mishi started licking it excessively causing it to be more inflammed today with the hair loss. I recommend using a cone on him to prevent licking. Then clean the area with hydrogen peroxide and you can apply a thin film of cortisone cream on it to soothe the skin. If it isn’t improving then you should bring him in for an exam and treatment. This will continue to get worse if he keeps licking the area. Thanks for using Petco Pet Education Center, formerly Petcoach to help you care for Mishi.