My cat has high calcium. What tests are needed to find the cause?
According to the PetHealth network, testing involves:
Complete blood count to look at the white and red blood cells and platelets
Chemistry panel to look at the kidney and liver function
Electrolytes to look at the calcium, phosphorous, and salt balance (e.g., sodium, potassium, etc.)
Urinalysis to look for the presence of an underlying infection, crystals, or appropriate urine concentration
Urine culture to rule out an underlying urinary tract infection
Feline leukemia (FELV) and feline immunodeficiency virus (FIV)
X-rays to rule out underlying cancer, bladder stones, or evidence of mineralization of tissue (secondary to hypercalcemia)
Ultrasound to rule out underlying cancer, bladder stones, or inappropriate mineralization
Parathyroid hormone (PTH) and PTH-rP concentration (parathyroid hormone related protein) levels. With hyperparathyroidism, the PTH levels are typically normal to high. With hypercalcemia of malignancy, PTH-rP concentrations are typically elevated. With idiopathic hypercalcemia in cats, PTH levels and PTH-rP levels are typically low.
This can be expensive, but necessary to get to the cause. I would speak to Sammy's vet to discuss what tests should be done first. Best of luck.
Updated on September 23rd, 2025