What sedatives are safe for an anxious small dog flying on a plane?
Several different drugs are available for this purpose. The drugs I use the most often for this sort of situation include trazodone, alprazolam (Xanax), and acepromazine. The last of these drugs will not provide any relief for anxiety for Muttley, instead it will simply tranquilize him. The other two will have both sedative and anti-anxiety activity. Discuss the situation with your veterinarian and determine which option you believe will be best. Hope this works out. If your pup is going to be travelling in the cabin, for the sake of the other passengers the use of the tranquilizer may be the best option.
Updated on September 23rd, 2025