Trifexis

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Related Articles & Questions

Health & Wellbeing
Simparica Trio vs. Trifexis: Best Flea & Tick Med for Your Dog?
Unsure which flea & tick medication to choose for your pup? Check out our comparison of Simparica Trio vs. Trifexis to see which product will work best for your dog!
Updated on November 13th, 2025
New Pet
Protect Your Pet: Flea & Tick Control Solutions for Dogs & Cats
Learn how to remove flea and ticks. Petco has flea and tick removal services for dogs and cats. Get fleas and ticks removed at your neighborhood Petco.
Updated on November 13th, 2025
Health & Wellbeing
Probiotics for Dogs: Optimize Digestion & Immunity for Health
Learn how to improve your dog's life with nutritional probiotics. Help your dog regardless of age or size & manage inflammation, gastrointestinal health & arthritis.
Updated on November 13th, 2025
Health & Wellbeing
Clavamox for Dogs & Cats: Treat Infections & Keep Pets Healthy
Do you think your pet has a bacterial infection? Visit Petco to learn how Clavamox can help your dog and cat.
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Health & Wellbeing
GlycoFlex: Your Guide to the Best Joint Support for Pet Mobility
GlycoFlex is a joint support supplement typically prescribed to dogs and cats. Visit Petco and learn uses, dosage, side effects and more. Get it online or in store now! 
Updated on November 13th, 2025
Health & Wellbeing
Hi, I am preparing to adopt an adult Alaskan klee kai. She is between 18 and 20 pounds. I currently live in Phoenix, AZ, but may be moving in the near future. I am trying to determine which flea/tick and heartworm preventatives may be best for her. I
Congratulations on your new dog! I like Revolution if you are looking for a topical product. It consistently works well and is well tolerated. If you like the idea of an oral product better, I like Trifexis (it’s another all in one product). Sometimes though the pets can smell the Trifexis and they won’t eat it. In that instance, I like Simparica and Interceptor. My personal preference is oral products. I hope this helps and please feel free to post any additional questions.
Updated on August 12th, 2025
Health & Wellbeing
I just gave Sophie her Trifexis and even though she is now 7 months, she still has the same side effects from the pill. Lethargy, upset stomach, and general feeling miserable. She had worm issues when she was a few months younger and dont want that t
I definitely would not continue giving Trifexis if she is continuing to have this reaction every month even if you give it on a full stomach. This is not normal and I have seen these reactions only get worse with time. I would strongly recommend you to switch her to something else like heartgard plus, advantage multi, or even the proheart injection. I would talk to your vet about what they recommend depending on the type of worms she had in the past. Different heartworm preventions work to prevent different types of worms. I hope this helps!
Updated on August 12th, 2025
Health & Wellbeing
Can I give my puppy Trifexis and a dewormer/Febendazole at the same time?
Hello and thank you for reaching out to Boop by Petco. Yes, these medications are safe to give together. I recommend offering a small meal or treat beforehand so that there is a little food in her stomach before getting these medications. She can also get a small tasty treat afterward so she knows she a good girl! I hope this is helpful - she is VERY cute!
Updated on August 12th, 2025
Health & Wellbeing
If I give my puppy TriFexis for the various worms and fleas, can I comebine it with anything to protect against ticks as well? TriFexis doesn’t cover ticks. I prefer an oral treatment versus topical or collars. Any recommendations? I can also swap ou
It is generally not recommended to use two oral products together. It's not to say it's impossible but many of these companies have not done the testing to know if there are interactions. You may discuss this with your regular vet to see if they have any experience with this. Most topical flea and tick products are expected to be safe to use with Trifexis. There is also a collar called a Preventic which is fine to use with oral products. Most people only put the collar on the pet when it is going out to tick areas and they remove it when the pet is not in those areas. Another option is to ask your vet if they would exchange the product for something like Simparica and Interceptor which would get all your parasite concerns. Some clients will also switch products when ticks are in season or when exposure is expected and then switch back once the exposure time is over. I hope this is helpful and please feel free to post any additional questions.
Updated on August 12th, 2025
Health & Wellbeing
I just adopted a dog at Petco and Humane society had given her Sentinel. Should we keep her on that or can I switch her to Trifexis, since that's what we give our other dog & I already order through Dr.'s Foster & Smith? Thanks.
Hi, thanks for using Boop by Petco! Switching to Trifexis is fine. Just be aware that Trifexis doesn't get ticks (neither does Sentinel, it is just heartworm, GI parasites and sterilized female fleas). I hope this helps!
Updated on August 12th, 2025