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Simparica Trio vs. Trifexis: Best Flea & Tick Med for Your Dog?

Unsure which flea & tick medication to choose for your pup? Check out our comparison of Simparica Trio vs. Trifexis to see which product will work best for your dog!

Updated on March 30th, 2026

Stop Fleas, Ticks & Mosquitoes: Pet Pest Prevention for a Healthy Pet

You may have heard that flea and tick prevention are crucial for dogs and cats, but do you know why? Petco is sharing why and how to prioritize pest prevention for your pet.

Updated on October 23rd, 2025

Selamectin for Dogs & Cats: Stop Fleas, Ticks & Heartworms

Search Petco for information on selamectin for pets of all kinds. We have all the details on how to prevent heartworms & parasites to keep your pet healthy.

Updated on October 23rd, 2025

Protect Your Pet: Flea & Tick Control Solutions for Dogs & Cats

Learn how to remove flea and ticks. Petco has flea and tick removal services for dogs and cats. Get fleas and ticks removed at your neighborhood Petco.

Updated on April 9th, 2026

Interceptor vs. Interceptor Plus: Best Heartworm & Worm Med for Dogs

At Petco, learn more about the benefits & differences of Interceptor & Interceptor Plus dewormer for dogs with heartworm, roundworms, hookworms & tapeworms.

Updated on October 23rd, 2025

My dog gets ticks on Simparica. What's best for high-risk areas?

The active ingredient in Simparica is sarolaner. At this time, there are no known drug interactions reported with sarolaner. I would therefore use a spot on treatment for fleas and ticks like Frontline or K9 Advantix II. I hope this helps!

Are Tri-Heart Plus & Simparica good, affordable heartworm & flea meds?

Hello. This is fine to use. I would not recommend giving both of these on the same day. Give one on the first of the month & the second on the 15th so there are no drug interactions. Thanks for using Boop by Petco.

My dog has flea allergies. Can I use Simparica and Advantix?

They are each labeled for once a month so it is safe and will be more effective if you alternate them every 2 weeks instead of using them at the same time each month. make sure the environment stays treated also to minimize what gets on him.

Choosing flea, tick, heartworm meds: Revolution, Advantix, Heartgard?

Congratulations on your new dog! I like Revolution if you are looking for a topical product. It consistently works well and is well tolerated. If you like the idea of an oral product better, I like Trifexis (it’s another all in one product). Sometimes though the pets can smell the Trifexis and they won’t eat it. In that instance, I like Simparica and Interceptor. My personal preference is oral products. I hope this helps and please feel free to post any additional questions.

Is Simparica safe and effective for my tiny chihuahua's ticks?

Simparica works efficiently against flea and ticks. Covering ticks is very important and this product is excellent. Discuss with your veterinarian a possible treatment for heartworms as well though as simparica does not cover for that. Hope this answer was helpful, but please do not hesitate to contact us again on the forum or by requesting a consultation if you have any more questions or to discuss it any further.