Simparica Trio Prescription Flea & Tick Medicine

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Health & Wellbeing
Simparica Trio vs. Trifexis: Best Flea & Tick Med for Your Dog?
Unsure which flea & tick medication to choose for your pup? Check out our comparison of Simparica Trio vs. Trifexis to see which product will work best for your dog!
Updated on October 29th, 2025
Health & Wellbeing
Selamectin for Dogs & Cats: Stop Fleas, Ticks & Heartworms
Search Petco for information on selamectin for pets of all kinds. We have all the details on how to prevent heartworms & parasites to keep your pet healthy.
Updated on October 29th, 2025
Health & Wellbeing
Stop Fleas, Ticks & Mosquitoes: Pet Pest Prevention for a Healthy Pet
You may have heard that flea and tick prevention are crucial for dogs and cats, but do you know why? Petco is sharing why and how to prioritize pest prevention for your pet.
Updated on October 29th, 2025
Health & Wellbeing
Flea & Tick Prevention: Oral vs. Topical - What's Best for Your Pet?
Most pet parents are familiar with topical or oral flea and tick preventives. So which is better for your pet—topical or oral?
Updated on October 29th, 2025
Health & Wellbeing
Safely Switch Your Pet's Flea & Tick Medication for Optimal Health
At some point in your pet’s life, you might want to switch from one flea and tick medication to another. So, how do you make the transition?
Updated on October 29th, 2025
Health & Wellbeing
I cannot find my dog’s regular flea/tick meds (topical Revolution 20.1-40.1lbs) b/c it’s on back order even with my vet. I’m panicking b/c idk what to give my dog that is equivalent to that flea/tick med. She hasn’t missed a single dose since she was
Simparica Trio is a similar medication that treats fleas, ticks, heartworms, roundworms, and hookworms. It's a chewable tablet rather than a topical, but is easy to give and can help bridge the gap until you're back on your regular medication. It is best to confirm it is safe to give with your vet if Mia has any other underlying health conditions or issues, and your vet can order it or provide a prescription to an online service such as Chewy.
Updated on August 12th, 2025
Health & Wellbeing
So I have a puppy and an adult dog I gave the puppy (6/7 months) the adult simparica trio drug and the adult one the Puppy one without realizing it. My mom had them out of cases and I thought they were the same it was the 11ib one and the 22-44 pound
Hello and thank you for contacting Boop by Petco. You should monitor Purl for symptoms of vomiting, lethargy, lack of appetite, tremors, problems with balance. If you notice any of these signs, you should get your puppy checked by your local vets right away. According to the manufacturer's data the symptoms are NOT likely to develop after ingesting this dose. You should give your bigger dog another tablet to get the right dose for 22-44 pound weight (that should be 24mg of sarolaner, moxidectinum 0.48mg and pyrantelum 100mg).
Updated on August 12th, 2025
Health & Wellbeing
Would you recommend Tri-Heart Plus Chewable Tablets for heartworm and Simparica Chewable Tablets for fleas and ticks? I want to get the right brand, but I'm worried about the cost, and these were some of the cheapest I found.
Hello. This is fine to use. I would not recommend giving both of these on the same day. Give one on the first of the month & the second on the 15th so there are no drug interactions. Thanks for using Boop by Petco.
Updated on August 12th, 2025
Health & Wellbeing
Hello we are due to update both of our dogs on flea and tick chews.
The easiest way to do so is to go to your veterinarian and either buy the chews from him or get a prescription from your vet and get them over the internet. I am assuming you are looking to buy either Bravecto, Simparica or Nexgard. These are prescription only.
Updated on August 12th, 2025
Health & Wellbeing
I have a 14-month-old mini Australian Shepherd who tested clear on the MDR1 gene mutation, no known health issues. He’s taken Trifexis for 11 months for flea/heartworm prevention, Simparica added 3 months ago for tick prevention. Meds are given with
It is ok to give trifexis and simparica together (staggered by 2 weeks is great). Both of those medications will protect against fleas so there is some overlap with that. If you want to streamline how many medications you are giving Dakota monthly, Another option would be to use sentinel or interceptor instead of the trifexis and give with that with simparica monthly. These products contain the same heart worm preventative (milbemycin) as trifexis but do not contain any medication to kill adult fleas. (Trifexis contains both the milbemycin for heart worm prevention and Spinosad for fleas). That way you would be giving one medication for heart worm prevention (sentinel or interceptor ) and one for flea and tick prevention (simparica). Another option is to continue trifexis and add in a tick collar (such as the preventic collar or the seresto collar). I know there are so many products and options it is confusing ! Let us know if you have any other questions. And great job with preventa
Updated on August 12th, 2025