Will car travel stress interfere with my puppy's first vaccination?

Congratulations on your new puppy! I've been in this situation as well, driving several hours home from a breeder's house with a new pup who needs to pee :) Your puppy will almost certainly need to go to the bathroom at some point during the trip - so yes, you'll need to stop somewhere. As long as he has started his vaccine series, his risk of contracting parvo or other diseases is really quite low as the vaccines are very effective... so you should use common sense and not put him in high-risk situations, but there's no reason that he can't walk in the grass for a few minutes to potty. I do normally recommend avoiding rest areas and other places that large numbers of people walk their dogs - instead, stop at a fast food restaurant or a gas station a mile or two from the highway, since this should be a much lower-traffic area in terms of strange dogs. And yes, I would recommend a crate for the car ride, for safety. Put a soft blanket and a toy or two from the breeder's, if she has one that she can send so that he has something that smells familiar.

I don't recommend to give a new puppy something for car sickness as Lady is very young and she may not have issues with car sickness. It will help to make sure she is not given any vaccines or dewormers within 24 hours of her trip. Keep her in your lap in the back seat or have her carrier easily accessible. Try to take a towel or something with the scent of her mother. Hopefully you will have a quiet trip back home. Congratulations and best of luck!

Yes, as long as he wil not be exposed to other dogs. The only concern about puppies traveling after vaccines is the risk for vaccine reactions. Most vaccine reactions happen within hours of the vaccine. So if after 2 days, he is not showing any symptoms of reaction (extreme lethardy, vomiting, diarrhea, swelling, hives, difficulty breathing), he will likely be fine.

Yes, 7-10 days after final vaccine should be fine to be out and meeting other dogs. Travel sickness generally does improve with time and sitting with him in the car on the driveway with a favorite chew toy etc so he can associate it with a resting place can be very helpful, follow by turning on the engine whilst stationary so he can get used to the vibration and take him on many short joourneys as soon as he is used to it. Natural calming supplements can help and there are prescription anti nausea medications available should you need to go on a long journey before he is ready

1)He can have his puppy shots before the trip. The vaccinations actually activate the immune system (this is what vaccinations do). 2)You can stay at a pet friendly hotel, however I would leaved him in a crate so he cannot run around and sniff possible "left-behinds" from other dogs. It would bot be advisable to let him sleep out in the cold at this age. While you are on the trip do not let other people pet him or touch him. Do not let him get in contact with dogs other than your own vaccinated dogs. He should be alright then.

In my opinion it is not a very good idea. The main reason is that your puppy has not been vaccinated yet and at the age of 8-10weeks puppies become susceptible for many infections (including parvovirus). Viruses, such as parvovirus, can be passed on puppies even without direct contact with infected dogs. The virus can be transmitted for example via schoes dirty in soil, cloths, could be picked up in carparks etc.

You should give home a lot of exercise on each day before the trip if possible. A tried dog has less energy for anxiety. Here is a helpful link about traveling with a pet in general: https://www.petcoach.co/article/dog-travel-safety-tips/ You may want to call your veterinarian to ask about anti-vomiting medication just in case. Some puppies will be prone to car sickness. You may also want to make sure he is up to date on vaccines and ask if he needs any flea or heartworm prevention. You may also want to stuff treats into a kong and then seal it with peanut butter. This may help to entertain him. You may also invest a 1 or 2 new toys that he may be excited about since they are new. Also make sure to offer him water regularly. Best of luck!