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Weight loss can be a sign of intestinal worms, organ dysfunction or disease (pancreatic insufficiency, liver shunts, kidney disease, liver inflammation/infection, etc.), food allergies or poor diet, and many other conditions.
Hair loss can be due to parasites (mange, fleas, etc.), hypothyroidism, allergies (food or environment), immune diseases, etc.
Given that Kalu is 2 years old, I would start by getting him dewormed and also get a product that treats for fleas, ticks and mange. See if his problems resolve. If they do not, then see your vet about testing.