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Why is my Lab still having seizures with high creatinine?

Updated on September 23rd, 2025

Pet's info: Dog | Labrador Retriever | Male | neutered | 97 lbs

four year old lab started having seizures about two weeks ago. He had three in one day and we took him to the vet--they ran blood work and found that his BUN was slightly elevated as well as his creatine kinase. We were told to kick his water up and bring a urine sample--they tested that and it was fine. We did a second round of blood work a week after his first seizures and the BUN returned to normal but his Creatinine was still elevated. He's had two more seizures today-switched food today

1 Answer

Most Helpful Answer

Answered By Dr. Massimo Orioles, DVM, Cert AVP, MRCVS

Veterinarian

Published on December 14th, 2017

The meaning of elevated creatinine and urea must be interpreted looking at a urine sample and urine specific gravity. If the urine specific gravity is elevated with elevated UREA and CREA that means that the kidneys are working correctly (or at least 30% of the total kidney functionality is preserved).
Other investigations for seizure must be performed as the underlying cause has not been recognized yet.
Generally speaking there are three main type of seizure causes:
-primary (something involving the brain itself like an infective disease, a cyst, a benign or malignant tumor)
-secondary: metabolic basically, which means a problem involving kidneys, liver and other organs and secondarily affecting the brain
-idiopathic: basically a genetic problem.
Your veterinarian can usually do part of the investigations like blood test but the rest may need an MRI and more advanced investigations.

Please do not hesitate to contact us again on the forum or by requesting a consultation if you have any more questions or to discuss it any further.

1Pet Parents found this answer helpful

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