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Dog on prednisone: How to stop safely? Are thirst and fatigue normal?

Updated on September 23rd, 2025

Pet's info: Dog | Mixed Breed | Female | spayed | 3 years and 1 month old | 28 lbs

My dog was prescribed with prednisone tablets and griseofulvin tablets last Friday for itchy skin. Can I just stop giving her the medicines or should I slowly wean off the meds? If slowly wean off, how do I do it for both the tablets? My dog was given 10 prednisone tablets, each 5mg for twice a day and 10 griseofulvin tablets, each 125mg for once a day. It has been 5 days now since my dog ate her medicines and has been very weak, tired and thirsty since then. Is that a problem to be afraid of?

1 Answer

Most Helpful Answer

Ricardo Fernandez, DVM

Answered By Ricardo Fernandez, DVM

Veterinarian, Veterinary Oncology Resident

Published on December 4th, 2018

Thanks for using Petco Pet Education Center, formerly Petcoach! Being tired and thirsty can be linked to the prednisone. Prednisone specifically should not be discontinued abruptly and needs to be tapered slowly. The tapering of the prednisone has to be done carefully and calculated based on the weight of the patient. I recommend you check in with your veterinarian who prescribed the prednisone for the tapering schedule for it as they have all the information they need for this. They can also advice on the other medication. Best of luck!
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