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Updated on September 23rd, 2025
Can my dog take prednisone and apoquel at the same time?
4 Answers

Answered By Destini R. Holloway, DVM
Veterinarian
Published on August 2nd, 2016
Answered By Destini R. Holloway, DVM
Veterinarian
Published on October 13th, 2017
I wouldn't advise that because Apoquel is weight dependent, so your pet Mindy may acutally need a different dosage than your oether pet. The dosage chart for Apoquel is very specific to the pets weight.
I would instead look into why your pets are itching. I would suspect fleas may be the cause, especially if both pets never had skin problems before. Getting them both on a good high quality flea preventative (i.e. Simparica, Nexgard, Bravecto, etc) is best, if not done so already. Then its best to get Mindy seen by your vet as well before making the assumption that Apoquel would be indicated for her skin condition also. Plus you wanat to get a full dose for her, if this is in fact the medication that she needs to be on. I hope this helps and best wishes getting to the bottom of your pets itchy skin woes. Take care.
1Pet Parents found this answer helpful
Answered By Linda G, MS, DVM
Veterinarian
Published on March 23rd, 2021
Hello. Unfortunately, very few dogs will respond in any way to Diphenhydramine. It really is not of much use for allergies in dogs. You might look at what some of the on-line pharmacies are charging for Apoquel & then request a prescription from your veterinarian. You might find it a little cheaper on Chewy, PetMeds, or one of a dozen pet pharmacies out there. Good luck & thanks for contacting Petco Pet Education Center, formerly Petcoach.
1Pet Parents found this answer helpful
Answered By Jessica Keay, DVM
Veterinarian
Published on July 14th, 2019
I am sorry to hear about your pup! Allergies can be so frustrating for dogs, owners, and their vets! We do have many dogs on long term apoquel who do wonderful, but there are other things that can be tried in dogs with allergies. You can ask your vet if they can refer you to a veterinary dermatologist if they do not do allergy testing at their hospital. Allergy testing can be done either by collecting a blood sample or by doing a skin test as they do in humans. Based on the testing they can develop allergy shots that can be given to desensitize your dog to the allergen, but this can take a good deal of time to help so often we need a combination approach. If food allergies are suspected then a trial on a hypoallergenic diet provided by your vet (a prescription diet is recommended not an over the counter diet) may also be recommended. These things may help decrease the need for drugs like apoquel.
6Pet Parents found this answer helpful