Dog on phenobarbital for seizures: lethargic, thirsty, wobbly. Normal?

Hello and thank you for contacting Petco Pet Education Center, formerly Petcoach. Molly should take phenobarbital to avoid further seizures, which is a priority in this situation. You should continue with the dose she has been prescribed. Many dogs are lethargic after the first few doses of phenobarbital but then are back to normal. Please, get in touch with your vet on Monday to confirm that Molly is on the right dose of phenobarbital. If the lethargy and lack of appetite persists, your vet will likely decrease the dose or change the medication. Molly will probably stay on anti-seizure medication for life.

Thanks for using Petco Pet Education Center, formerly Petcoach! Those are likely side effects from the phenobarbital. For that reason, I would highly recommend that you contact your veterinarian as they may decide to decrease his dose of phenobarbital based on this. Best of luck!

Hi there and thank you for using Petco Pet Education Center, formerly Petcoach to address your concern. In the initial stages of starting Phenobarbital, dogs develop what we call transient symptoms. These include becoming wobbly (ataxia), drooling, disorientation, panting, etc. These symptoms will eventually subside as the dog's body becomes used to the phenobarbital. If Trapper is no longer having seizures, I would call the veterinarian and ask if the dose can be slightly lowered. I hope this helps! Please let me know if you have any other questions or concerns and I would be more than happy to help you further.

Hi, thanks for using Petco Pet Education Center, formerly Petcoach! No, I wouldn’t be concerned about the extra phenobarbital. It could cause minor sedation. If he is very lethargic it is unrelated to the medication. I would encourage a vet exam for the foot injury if he is worsening. Have a great day!

It could be a very bad side effect of the phenobarbital, it is a strong medication that tends to cause severe side effects, especially if given at a loading dose in the beginning. you should contact your vet immediately in order to discuss possibly changing the dosage.

Phenobarbital therapy in dogs is begun at 2 to 4 mg/kg twice daily. So for a 33kg dog that would mean 66 to 132 mg twice a day. We always try to start low and increase if needed but he was essentially really underdosed in the beginning with taking 30mg twice a day. He is now on a more appropriate dose. Sedation is normal when therapy is initiated but once the dog's body gets used to the drug (after about 2 weeks) he should become more like himself. If you are really worried, you can ask the vet to run a phenobarbital level blood test to see if his dosing is too high and it can be adjusted accordingly. Please be aware that dogs will never be completely seizure free even while on anti-seizure medication. Breakthrough seizures are common but they should be pretty infrequent. If he continues to seizure or does not do well on the phenobarbital there are other medication options so please work closely with your vet.

I wish I had a little more information to help you with this question. IF she is just starting the medication and is on a loading dose then she could just be pretty drunk from the medication and may improve in time as her body adjusts. However, if she has been on the meds for a while and these are new changes then I would be concerned that this may be part of her underlying neurologic problem and not due to the meds. Regardless, I would encourage you to follow up with your veterinarian soon. In the meantime if you have other questions I would encourage you to request a consultation for more direct question and answer and “discussion” format. Best of luck and thank you for using Pet Coach.