My dog has lymphoma, why did his neck tumor swell overnight?
Hello and thank you for reaching out to Petco Pet Education Center, formerly Petcoach. I'm sorry to hear that Thunderbolt has lymphoma but I'm happy he has been doing fairly well with his prednisone. It is possible that this area could be his lymph node which has swollen/grown significantly in size. This can happen pretty acutely, over the course of several hours to a day. This would suggest that his lymphoma is progressive, and his body may not be responding to the prednisone any longer. There are other chemotherapeutic options that may benefit Thunderbolt. I worry that a mass on his neck could continue to grow and possible cause difficulty breathing or swallowing. I recommend having Thunderbolt evaluated by your veterinarian to determine what the swelling is exactly (lymph node vs. mass vs. abscess, etc), and discuss other treatment options. I hope this is helpful!
Updated on September 23rd, 2025