My dog has lymphoma and is on prednisone. Why is he so agitated?

Thanks for using Petco Pet Education Center, formerly Petcoach! I am sorry to hear Diesel isn’t feeling well. The prednisone is supposed to help slow the growth of the cancer but eventually it won’t be effective. Prednisone alone isn’t enough to cure him. If he is getting worse and the lymph nodes are growing it is likely the prednisone is no longer helping. I would discuss your options with the vet that diagnosed him but there isn’t much more they can do for him. I am so sorry and I hope the rest of his life is pain free. Good luck and kisses to Diesel!

Max is already on a high dose of prednisone and I doubt increasing the dose would improve his symptoms. Prognosis depends on the type and stage of lymphoma, but in general the median survival time with prednisone is about a month. I'm so sorry about Max's diagnosis.

I'm sorry to hear this is happening. I recommend to call your vet. This could be a side effect from the medication or it could indicate his lungs are filling with fluid from the cancer. I hope they figure out a solution quickly.

Prednisone can absolutely cause behavior changes and mood alterations. The side effects are usually at their greatest during the first two to four week of therapy as the body grows accustomed to glucocorticoid drugs. The metronidazole is not likely a cause of any side effects you are currently seeing. If you are consulting with a oncologist regarding Pepe's case, do not hesitate to contact them with any questions involving his therapy. These cases can often be complex and require a lot of special attention to drug interactions. Anyway, if you require further consultation please let me know. Hope this makes sense.

I'm sorry to hear that Daisy received this diagnosis. There are certainly risks and benefits to both options with respect to side effects, life span and cost. Side effects of prednisone in the short term can cause excessive drinking and urination. Some animals with underlying heart disease can go into congestive heart failure and other animals can develop diabetes as a result of the high doses of corticosteroids given in these situations. Around 40% of dogs can achieve remission for 4-6 weeks with prednisone alone, but this is certainly based upon an individual's response to medication and if any metastatic (spread) of disease is present. Obviously, this treatment is much less expensive, but a much shorter survival time is expected. Daisy's chemotherapy protocol is based on whether she has B cell or T cell lymphoma and if any metastatic disease is present. As a generalized statement, lymphoma responds to chemotherapy better than most cancers. Oncologists strive to administer chemotherapeutic drugs at doses that will kill cancerous cells while avoiding as many side effects as possible. The side effects possible vary with different chemotherapeutic drugs. In short, there is no right or wrong choice. You need to evaluate both options to determine your comfort level. If you haven't already done so, consider a consultation with a veterinary oncologist for more information. I hope this helps!

Poor Sasha! I would talk to your vet before giving her her next dose. She may just not be able to tolerate that large of a dose at once. Your vet may be able to adjust the dose for her. If she isn't eating or drinking and c mutinies to be lethargic then I would recommend taking her back to your vet for another evaluation to ensure there isn't anything else causing her to be so lethargic. I am sorry you receive bad news and that she is having to go through this. Please know you are in my thoughts and I hope she starts to feel better really soon.

Hi there! Thanks for using Petco Pet Education Center, formerly Petcoach! This is a common question I encounter as I only see cancer patients and lymphoma is very common in my practice. Prednisone is good for lymphoma though as you are noticing, lymphoma will eventually progress, as noted by peripheral lymph node enlargement. Normally, lymphoma will not cause clinical signs for some time until it enters more of the end stage. Lymphoma is not typically a painful disease and it is more of a debilitating disease. For this reason, what you will notice at the end is clinical signs such as lethargy, decreased appetite and Brandi just not being interested in the normal things that she enjoys. The median survival time of dogs with multicentric lymphoma just on prednisone is about 2 to 2 and 1/2 months. Usually I tell my clients that the time to consider humane euthanasia is when they are not doing 3 out of their 5 favorite things. Good luck with your girl!