How to help my dog with liver disease, Cushing's, and weight gain on phenobarbital?

Hello and thank you for contacting Petco Pet Education Center, formerly Petcoach. Molly should take phenobarbital to avoid further seizures, which is a priority in this situation. You should continue with the dose she has been prescribed. Many dogs are lethargic after the first few doses of phenobarbital but then are back to normal. Please, get in touch with your vet on Monday to confirm that Molly is on the right dose of phenobarbital. If the lethargy and lack of appetite persists, your vet will likely decrease the dose or change the medication. Molly will probably stay on anti-seizure medication for life.

Hi and thanks for your request. The aim of the phenobarbital administration is to reduce effectively seizure frequency and severity. In my experience a frequency of once a month is fair and acceptable. Ideally Phenobarbital concentration should be checked 3 and 6 months after starting the treatment to monitor liver parameters and make sure the concentration of the drug in the blood is within therapeutic ranges. Dose could be even increased, but to be able to give you specific advices about it I would need to know Shadow's weight. Hope this answer was helpful, but please do not hesitate to contact us again on the forum or by requesting a consultation if you have any more questions or to discuss it any further. If this answer was helpful please let us know, this will be used to improve our service!

Hello and thank you for contacting Petco Pet Education Center, formerly Petcoach. I assume Chhutki was prescribed phenobarbital for seizures. This medication can produce transient elevation of liver enzymes, increased thirst, increased appetite, lethargy and weight gain. It does not affect kidney or heart function and does not cause gallstones formation. If you don't use any anti-epileptic medications for your dog, she will likely have more seizures, which can be longer/more severe than her first seizure.

Poor guy. The treatment is ok; however, if we suspect any kind of liver involvement there are safer anti-seizure medications to consider here such as Zonisamide or Keppra. Although we would suspect the ALT to be elevated over the ALP in most liver problem dogs. You should certainly discuss these concerns with your vet. This may be why the liver supplement was prescribed, in case there is liver involvement. I would also consider getting an abdominal ultrasound done on him to evaluate his liver and adrenal glands. Both these organs can cause the elevated ALP, so we need to check if this is the underlying problem for sure or not. And ultimately seizures should be evaluted via MRI/CT scan; however, the cost of this limits most pet owners from having this done. Here is more information on seizures --> https://veterinarypartner.vin.com/default.aspx?pid=19239&id=4951440 I hope that Milo's seizures stabilize and that he does well moving forward. Take care.

In theory this would help a pet that is being exposed to a potential liver damaging drug. It definitely won't hurt. It can be expensive however. But it is a good proactive thing to do to potentially help protect the liver from damage over time. Best wishes with your pet Tootsie moving forward. Take care. : )

It is doubtful that it would be the primary cause of her weight gain. As they age, their metabolism will slow down and usually the amount of food that they need is less. I would try to decrease the amount of food you are feeding her and increase her activity. If she is still gaining weight, I would have your vet check her thyroid to ensure it isn't low as this is also a common cause of weight gain. I hope this helps !

Hello there and thank you for using Pet Coach! There are multiple anti-seizure drugs available and some with less side effects than others. If Bailey is on Phenobarbital, Keppra may be a good option for him as this particular drug has fewer side effects and I find that it is less harsh on the liver. Switching to a different drug with less side effects will certainly help. You can also talk to your vet about prescription liver diets in addition to the Denmarin. Hepagen-C is a veterinary product that is over the counter, which we use at our clinic in conjunction with Denamarin or Denosyl. Your vet can also perform a Bile Acids test to determine how much function of the liver has been lost. A scan would certainly be recommended and there are sedative combinations and drugs that we can use that will not trigger seizures, as they are anti-seizure drugs that we use to control seizures. I would still recommend an ultrasound, but talk to your vet about the different drugs that can be used to prevent seizures while sedated. I hope this helps! Please do not hesitate to contact me with any other questions or concerns that you may have. I am also available via phone or text consultation if needed. Please remember to rate this post as helpful or not. Thank you!