My dog has high glucose, ALKP, pot belly, and pants. Is it Cushing's?

Cushing's or Hyperadrenocorticism is a fairly common endocrine disease in dogs. It can be caused by a bit of overactive tissue in the brain (in the pituitary gland, which is the master ruler of hormone secretion in the body) or a mass in an adrenal gland (sits by the kidneys, secretes hormones as directed by the pituitary gland). Basically what happens is an excess of a hormone in the body, usually a steroid called cortisol, if it is traditional Cushing's. This then causes some symptoms in the pet, blood work changes, and sometimes other changes like high blood pressure. I suspect based on the value that you report that this was a liver enzyme elevation call ALP. This very commonly occurs in pets that have Cushings, but is not specific for Cushing's and elevation can be caused by other disease processes. This value does not correlate with severity of disease as many dogs have a high value. It sounds like your vet is on the right track by recommending an ultrasound to look at the adrenal glands and also the rest of the abdominal organs to rule out other disease processes. Ultimately Cushing's Disease has to be diagnosed by some sort of endocrine testing which your vet may recommend as well. Treatment if then based on what type of Cushing's disease is present. I hope this helps and thank you for using Petco Pet Education Center, formerly Petcoach!

My biggest concern is that your vet is talking about hyperadrenocorticism also known as Cushing's disease. This is what I think of when you discuss those symptoms, liver enzyme elevations and adrenal issues. Cushings is where they produce too much cortisol in their system. You can do a test to rule this in or out. You can have your vet do a low dose dexamethasone test OR a ACTH stimulation test. If it comes up positive then you can treat with the disease with a daily medicine called trilostane to help the symptoms. But you cannot cure cushings. I hope this helps and will help guide you in a conversation with your vet if this is actually what your vet thinks is going on.

Hi there and thank you for using pet coach to address your concern. The ALP is quite high but this also depends on their reference ranges there. The symptoms you are describing could be consistent with a condition called hyperadrenocorticism (Cushing's disease) which is when there is excessive steroid production in the body due to a pituitary tumor or adrenal gland mass. There is treatment for the disease but it needs to be confirmed first. If you want to know for sure, testing such as an ACTH or low dose dexamethasone test should be performed. You can try using melatonin and flaxseed lignans to treat cushings disease naturally. I have had some cases respond to this treatment but not 100%. Also, I see that cre is 18. If this is creatinine, this is very high. Again, this depends on the machines reference range, calibration and unit of measure. Creatinine elevates typically with renal disease, which could also explain the increased thirst. If you attach a picture and repost to the forum here, it may help us better guide you. I hope this helps! You can visit a website called lignansforlife.net and order the holistic medications that I spoke of earlier. Please let me know if you have any other questions or concerns and I would be more than happy to help you further.

I'm sorry to hear about Chi Chi's recent issues. Vomiting and an anal gland abscess/rupture may cause some changes on the blood panel, but not typically ALP. When you have a significantly elevated ALP and normal ALT it is highly suggestive of Cushing's disease. Cushing's can be diagnosed with a few different tests, these tests involve taking blood, injecting a substance then taking blood again to see the body's ability to respond. I think it would be wise to have her checked. If she dies have Cushing's thankfully it is treatable with medication but this will be for life.

I'm sorry that Miller is not feeling well. We certainly see an increase in ALKP as an early sign of Cushing's disease, but ALT is not as commonly elevated. I am attaching a handout with more information about Cushing's disease below. https://www.veterinarypartner.com/Content.plx?P=A&S=0&C=0&A=1551 The most common test that we will use to diagnose Cushing's disease is called a Low Dose Dexamethasone Suppression Test. I am attaching a handout below that discusses the specific tests we use for Cushing's disease. https://www.veterinarypartner.com/Content.plx?P=A&S=0&C=0&A=636 However, an abdominal ultrasound is also an excellent test to evaluate the adrenal glands to look for evidence of Cushing's disease. So, I would discuss with your veterinarian if they would recommend doing further blood testing first or an abdominal ultrasound. That answer will likely depend on what Miler's lab work looks like when it is rechecked in 2 weeks. Good luck! I hope that was helpful and you can figure out what is going on with Miller. Thanks for using PetCoach.

This could be a possibility. If your vet thinks Cushing she could be complicating her diabetes, you could consider testing her for cushings. If she definitely has cushings then you can start treating her for that. In the meantime, y'all will need to work on getting her diabetes under control. Another option would be to see if there is a specialist (internist) near you that could take over her case to help you get the DKA under control while also diagnosing and treating for cushings if needed. The main difference between a specialist and a general practitioner is that the specialist specializes in these complicated metabolic diseases and usually have facilities and specialized equipment that can care for them 24 hours if needed. If there is a cost concern and yall are unable to get the DKA under control and she is continuing to decline then yes, I would consider euthanasia. Unfortunately, even with intensive care and extensive testing, sometimes these guys don't improve and continue to decline no matter what we do. I know this is a difficult time and decision. Just know that you are doing the best thing for her whatever you decide. I hope this helps and know we are thinking of you. Hugs!

An enlarged liver is unfortunately one of the common side effects of Cushing's disease so it is not unusual that Ginger's liver appeared enlarged. Her urine concentration is very low (normal for a dog is 1.040) but again, this can be attributed to her Cushing's disease as well (because she is probably drinking more water and therefore causing her urine to be more dilute). In Ginger's case I would be worried about Diabetes and possibly cancer as well. I know it can be frustrating (and expensive) to keep doing more tests, especially when you aren't getting clear answers as to what is going on. I would recommend talking to your vet about costs/additional testing versus palliative care/keeping her comfortable for the time being. It may also be worth beginning treatment for her Cushing's disease because it could help allieviate some of her symptoms. Good luck. Please let us know if you have more questions/concerns.