My dog tested negative for Cushing's years ago. When to retest?

Typical signs of Cushing's disease in dogs are as follows: increased thirst and urination, increased appetite, less activity, thin skin, hair loss, excessive panting, possible recurrent skin infections, new pigmentation on the abdomen or comedones (blackheads). If you suspect your dog may have Cushing's disease, you need to make an appointment with your veterinarian for an exam and some blood tests.

My biggest concern is that your vet is talking about hyperadrenocorticism also known as Cushing's disease. This is what I think of when you discuss those symptoms, liver enzyme elevations and adrenal issues. Cushings is where they produce too much cortisol in their system. You can do a test to rule this in or out. You can have your vet do a low dose dexamethasone test OR a ACTH stimulation test. If it comes up positive then you can treat with the disease with a daily medicine called trilostane to help the symptoms. But you cannot cure cushings. I hope this helps and will help guide you in a conversation with your vet if this is actually what your vet thinks is going on.

Poor Nemesis. Sometimes pets will need the medication adjusted. I recommend to call your veterinarian and ask if another test is needed to evaluate the blood levels in his body. The test is called an ACTH stimulation test. It has been found that 50% of dogs with Cushing’s disease will also have a urinary tract infection that can only be detected with a urine culture. I recommend to have this test done as well as this will cause constant drinking and urination. Other conditions such as thyroid disease, diabetes or kidney disease can also cause these signs. You must start ruling them out. Best of luck.

Some common symptoms of Cushings's are panting, increased thirst/urination, but these are also common symptoms of many diseases. Bloodwork and endocrine testing can help to ferret that out. Neurologic symptoms can sometimes be present with Cushing's if there is a larger tumor in the pituitary gland but seizures can also be caused by other things as well so an MRI is typically required. CT can sometimes be used if a pituitary mass is strongly suspected. Itchy feet is typically caused by allergies which may also be associated with secondary infection. Next steps are to see your vet for an exam, bloodwork, and endocrine testing. Abdominal ultrasound and blood pressure measurement are also typical next steps. I hope this helps and thank you for using Petco Pet Education Center, formerly Petcoach!

Cushing’s syndrome (if that is indeed what she has), is rarely an emergency. Many dogs have had the disorder for months (or years) prior to diagnosis. However, diabetes can have very similar signs and that is more of a concern. If she has lost weight, or if she is not eating then I would recommend an emergency veterinarian to make sure she is not diabetic and starting to Decompensate. I also notice that she is not spayed. Pyometra is a uterine infection that usually starts with increased water intake, But they usually progress to not feeling well soon. Some of these dogs also have vaginal discharge and typically occurs 6 weeks or so after last heat cycle. If she is eating well and seem fine otherwise then waiting until Monday seems appropriate to me. If possible try to take a urine sample with you to your veterinarian appointment. Best of luck and I hope she does well. Thank you for using Pet Coach.

Although it is more rare to see Cushing's disease in a younger dog it is definitely still possible. I have definitely diagnosed Cushing's in a dog at this age, however it is still pretty uncommon. There are other possible causes of increased drinking and the other signs you've described so I think a veterinary visit is the best place to start. Instead of jumping right into a Cushing's work up I'd suggest starting with some baseline blood work, a thyroid level and a urine check. This will rule out some other potential causes and make it more clear if Lola should be checked for Cushing's disease. I hope this is helpful! Thanks for using Petco Pet Education Center, formerly Petcoach and good luck to you and Lola!

Hi there and thank you for posting your question. The medication used to treat Cushing's disease can cause some pretty serious problems if not monitored appropriately. Unfortunately, the blood testing to monitor Cushing's is expensive. For the first two to three months I will perform this particular test called the ACTH test to monitor the response to treatment and to make sure that the medication is not causing the reverse problem called Addison's disease. If the dog is well regulated I might spread out the blood test to once every 6 months to ensure that the values are regulated. Of course, this is something that you will have to discuss with your veterinarian who is ordering this blood test up every few weeks. Every doctor is different with how they monitor their patients, so not all of us will recommend the exact same plan for every patient. I hope this helps guide you in the right direction. Please let me know if you have any further questions or concerns and I would be more than happy to help you further.