My German Shepherd is losing weight. Can normal blood tests rule out EPI?
Hi and thank you for using Petco Pet Education Center, formerly Petcoach. I am sorry to hear that Uma is losing weight! Typically, EPI affects younger dogs, and you are correct, they typically affect German Shepherds. A lot of the time, the cbc and chemistry panels are normal. Occasionally, you can see elevated liver enzymes like ALT on the chemistry. However, to properly diganose EPI, you need to send out a special test to a specific lab. This blood test is called canine serum trypsin-like immunoreactivity. This is a direct look at the pancreas' functionality.
Given Uma's age, she less likely has EPI since she is almost 10 years old. Therefore, there may be another reason she is losing weight. If her bloodwork is all normal, then I would recommend abdominal radiographs or an abdominal ultrasound. Good luck and I hope she gets better soon!
Updated on September 23rd, 2025