My dog has autoimmune issues, low platelets, and allergies. Help?

Hi, thanks for using Petco Pet Education Center, formerly Petcoach! Poor Mollie! I wouldn’t do immunosuppressive doses of steroids without a biopsy. I would try a prescription hydrolzed diet like Royal Canin ultimino, put her on Bravecto, nexgard or simparica to cover for demodex and flea allergy dermatitis, omega 3 fish oil, allergy test her and try cytopoint. I think she has allergies. Most dogs with allergic skin disease need to be on multiple medications and special food. If that doesn’t work consider a boarded veterinary dermatologist. Then consider biopsy of the skin. I hope this helps and I wish Mollie the best!

I would also suspect an autoimmune disease like systemic lupus erythematosis with what you are describing. These are terrible diseases that are often difficult to treat. It appears that Roxy's current treatment is not very effective, so I would recommend scheduling a recheck exam with your vet. There are stronger medications that can be given. I would also want to ensure the disease is accurately diagnosed. This usually requires that a skin biopsy be done and sent to the laboratory for analysis. If this has not been done, then I would ask your vet about it. It's not unheard of for a case to be treated for autoimmune disease when the actual diagnosis was something different (i.e. skin cancer, mite infestation), so it's important to have a biopsy and histopathology (lab analysis) done. For more information about the suspected condition and autoimmune diseases, I recommend you read the short articles at the links below. https://vcahospitals.com/know-your-pet/systemic-lupus-erythematosis-sle-in-dogs https://vcahospitals.com/know-your-pet/autoimmune-skin-disease-in-dogs I hope that helps and poor Roxy gets better soon.

Hi, thanks for using Petco Pet Education Center, formerly Petcoach! There are a few possibilities that come to mind with what you are describing. Endocrine disorders such as diabetes mellitus, hypothyroidism, and hyperadrenocorticism (Cushing's) are some of the first places I would start. Under-devoloped or suppressed immunity can be some rare things such as bone marrow hypoplasia or a deficiency in specific cell signalling chemicals produced by the body or receptors for those chemicals. I would consider consulting with a specialist. If Hero's primary problem is with his skin, a dermatologist would be the one to see. If other infections are more prevalent, consider seeing an internist. Hope this helps!

The problem here is to establish the underlying cause of thrombocytopenia (low platelets). Immune-mediated thrombocytopenia is one of the most common causes. This process usually occurs in the spleen although the liver also plays a role. Thrombocytopenia develops as platelet destruction exceeds compensatory production by the bone marrow. Immune-mediated thrombocytopenia can be classified as primary or secondary. Secondary processes can be caused by infective diseases or tumors very commonly. Usually to determine a diagnosis more tests needs to be performed like abdominal ultrasound and chest x rays. Infective diseases like Ehrlichia, Anaplasma spp for example should be ideally evaluated as well. Hope this answer was helpful, but please do not hesitate to contact us again on the forum (where you can post pics of the blood tests) or by requesting a consultation if you have any more questions or to discuss it any further.

Hello and thank you for reaching out to Petco Pet Education Center, formerly Petcoach. I'm sorry to hear about Thunder, he sounds pretty sick. It sounds like you and your veterinarian are trying many different treatments for his low platelets. It is possible that he is suffering from an immune-mediated disease such as ITP, which is immune-mediated thrombocytopenia. This is where the immune system destroys the body's platelets. We can see this secondary to tick-diseases such as ehrlichia. He is already on prednisone, but he may require a second immune-modulatory medication, such as mycophenolate. This medication works with prednisone to reduce immune destruction of platelets. I hope this information is helpful, and best of luck trying to get Thunder's disease under control. I'm sure it is very difficult and frustrating for you.

Thanks for using Petco Pet Education Center, formerly Petcoach! This is possibly due to allergies. It really comes down to figuring out what is causing her allergies so that they can be treated or the specific allergen avoided. A secondary infection is likely and also needs to be addressed. There are many things that can cause allergies though in most cases they can be broken down into 3 big categories: flea, food and environmental allergies. Allergies are usually worked up in a stepwise fashion starting with flea allergies as this is the easiest and cheapest to take care of. If not on a flea preventative, then it would be a good idea to get started on one. If already on one then it would be a good idea to change to something else (there are many new products out in the market). If not improved in 1-3 months then it is time to move on and check for food allergies by switching to a novel diet (new protein and new carbohydrate). If that does not seem to be the issue then you are left out having to check for environmental allergies which require blood and/or skin tests. Allergies can be very frustrating to deal with at first but so rewarding at the end when we are able to treat them effectively!

Hi there and thank you for using Pet Coach to address your concern. If she has had history of an immune mediated disease such as immune mediated hemolytic anemia, I would get her in to see your veterinarian as soon as possible to check her lab values and see if this disease has returned. I would want to see what her red blood cells and platelet numbers look like. She may need to go back on immunosuppressants to stop the disease from progressing any further. The bruising on the abdomen has be concerned that she has a bleeding disorder. I hope this helps guide you in the right direction. Please let me know if you have any other questions or concerns.