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My dog is more aggressive on anxiety medication. Is this normal?

Updated on September 23rd, 2025

Pet's info: Dog | English Cocker Spaniel | Male | neutered | 2 years and 7 months old | 40 lbs

How long will the side effects of bisputone last? Giving my English cocker 15 mg a day. He is over aggressive with out other dog and his excitability is over the moon. Was prescribed for overall anxiety and frankly his over aggressive behaviors. Just need him to calm down enough to take direction. This side effect is not helping. Started med on 6/1. Will continue if side effects drastically subside. If not, will discontinue. Thank u

1 Answer

Most Helpful Answer

Destini R. Holloway, DVM

Answered By Destini R. Holloway, DVM

Veterinarian

Published on June 8th, 2017

Poor Walter. In some cases you are correct, the opposite effect is achieved and the pet becomes what we called paradoxically aggressive. This is not considered a normal side effect that will go away, but instead an adverse effect which has to do with how the pet metaboilzes the drug altogether. I would recommend discussing with your vet to stop the medication and try an alternative aggression medication at this time.
If he has inter-pet aggression, then I would consider trying Clomicalm or Prozac (Fluoxetine) as an alternative. Also don't forget that you have more success controlling behavioral issues with pets when you do both medical therapy + behavioral modification training with an animal behaviorist. https://iaabc.org/consultants
Best of luck with Walter and I hope you can get his behavioral issues resolved soon.
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