What shots does my 2-year-old dog need and how much do they cost?

She is a pretty girl!!! The most important vaccination (and one required by law) is the Rabies vaccine. This is essential. The second most important vaccine is the Distemper vaccine, which is often a combo vaccine sometimes called a DHPP (protects against distemper, canine hepatitis, parvovirus and parainfluenza). These vaccines are considered the "core vaccines" for dogs. Every dog should have them. The rest will depend on her lifestyle. I also recommend the Leptosporosis vaccine for dogs if they spend time outdoors in areas with creeks/puddles/ponds because this disease is a bacteria transmitted to dogs by contaminated water (rodents who have the disease urinate and it contaminates the water and the dogs can acquire it this way). The Lepto vaccine requries a series of 2 booster 3 to 4 weeks apart if she has never had it before. Other vaccines you may consider would include Lyme if your dog is outdoors and exposed to ticks and you are in a lyme endemic area, Bordetella also known as Kennel Cough if you ever take her to the park/groomer/kennel/dog classes/out for walks in areas with other dogs. Canine Influenza is another vaccine I recommend for dogs that come into contact with many other dogs/areas with many other dogs such as kennels or dog shows/events. That vaccine will also require a series of 2 vaccines several weeks apart if she has never had it before.