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Is 100mg Trazodone safe for my 20lb puppy with separation anxiety?

Updated on September 23rd, 2025

Pet's info: Dog | Mixed Breed Medium (23 - 60lb) | Female | unspayed | 4 months and 9 days old | 20 lbs

My dog was prescribed 100mg of Trazodone as needed for separation anxiety/sedation. I've been reading about normal dosages in dogs, and this seems like quite a bit to start off with. Is 100mg too much for a 20 lb puppy?

1 Answer

Most Helpful Answer

Lauren Jones VMD

Answered By Lauren Jones VMD

Veterinarian

Published on October 26th, 2017

The dose range for Trazodone in dogs is very wide. For use as needed, published doses range from 2.2-14 milligrams per kilogram (mg/kg) of body weight per day. Based on her current 20 pound body weight, Luna has been prescribed 10.1 mg/kg, which is a perfectly acceptable dose. There are limited studies of the use in Trazodone in dogs, but it seems to be a very safe medication and anecdotal doses have been safely reported in excess of the published doses mentioned above. Since Luna is still a young, growing puppy, expect her dose to increase over time as she gets older and bigger. I hope this helps and that all goes well in managing Luna's separation anxiety!
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