Should indoor adult cats get annual rabies, FVRCP, and FeLV shots?
I have attached the most recent recommendations from the American Association of Feline Practitioners (AAFP) below.
https://www.catvets.com/guidelines/practice-guidelines/feline-vaccination
Their general recommendation is to repeat the FVRCP vaccination every 3-4 weeks until a kitten reaches 16 weeks of age, then booster it 1 year later, then every 3 years after that. Unfortunately, we do not have enough data to give better recommendations than that.
Injection site sarcomas have dramatically decreased over the last 15 years since we have made some changes to our vaccinations and vaccination schedules. The kidney issues are more likely due to chronic mild dehydration. There is some concern that the FVRCP vaccinations are grown on renal cell cultures, but I am unaware of any good research in that area.
As far as FeLV vaccination, the AAFP generally does not recommend continuing to vaccinate indoor only cats who do not have a risk of exposure with FeLV vaccination. And Rabies vaccination is dictated by local or state laws, so if you live in an area that legally requires Rabies every year, you should comply with that.
The bottom line is that we try to protect all cats from as many infectious diseases as possible, but try to use the most recent research and the lifestyle of the cat to help determine which vaccines to give and how frequently to give them.
I hope that was helpful and answers your questions. Thanks for using PetCoach.
Updated on September 23rd, 2025