How to help my senior cat cope with long-term depression and grief?

There are calming supplements and diets which can be very helpful, as well as pheromone and comfort zone diffusers which can help cats adapt to such situations. A full health check and possibly blood panel should be considered to rule out medical causes especially if there is any weight loss or altered thirst

Thank you for contacting Petco Pet Education Center, formerly Petcoach with your question about Lilith. I agree that two months is a bit for grief, especially if they were not bonded. I see that she is an older girl, and so the first thing to do is take her into a vet for a health check. Even though she appears healthy, a sudden change in behavior can be the first sign of an illness. So have her seen by a vet in the next few days. I would also get a Sentry calming collar and a Feliway diffuser. Both release calming pheromones, and that may help with her behavior. While at the vet, if she checks out healthy, the vet can discuss other strategies to deal with this. I hope this helps!

I suggest you try some Feliway diffusers to see if it will help him. Give it a couple months to see if it helps. The diffusers must be changed every 30 days and you need to get enough diffusers to cover the square footage of the house. Also, some environmental enrichment would be a good idea. ( https://www.feliway.com/uk/Products/FELIWAY-CLASSIC-Diffuser ) ( thedrakecenter.com/materials/environmental-enrichment-indoor-cats ) ( https://www.youtube.com/watch?v=AejmrLa_Cs4 )

I would recommend having Lilly see a veterinarian. I would want to make sure it isn't medically related and more related to having the other cats gone. If they don't see anything medically going on I would recommend making sure you are spending extra quality time with her doing things she loves and then discussing medication with your vet. Thank you for using Petco Pet Education Center, formerly Petcoach.

Feliway pheromone plug ins, sprays or collars, as well as VetriScience Composure liquid given daily may help with her depression. Both are available online without a prescription. Introducing new toys, catnip and even a new cat under close supervision (after making sure that the new cat doesn’t have intestinal parasites, fleas, FeLV/FIV or other transmissible diseases and won’t get get your cat pregnant) may help as well! Good luck!

It is difficult to tell for sure without checking her over. It could be that her colitis is making her feel run down or it could be a slight worsening of one of her other conditions. I would recommend to keep an eye on how much she is drinking and how is her appetite and if she is having any vomiting. If she is just a little lethargic, I would book her in for a check up with your vet in the morning. Whilst if she is vomiting orhaving more diarrhoea than usual, I would recommend an earlier check up.

I recommend you put some Feliway diffusers in your house and do some environmental enrichment for her. Usually these two things help. https://www.feliway.com/us/Products/FELIWAY-CLASSIC-Diffuser thedrakecenter.com/materials/environmental-enrichment-indoor-cats  https://www.youtube.com/watch?v=AejmrLa_Cs4