How long does prednisone treat cat lymphoma & affect endoscopy?

Dexamethasone is 7 times stronger than prednisolone and has an increased rate of GI upset or stomach ulcers. Typically on prednisolone is used in cat because prednisone is broken down to prednisolone--so it is easier to start with the broken down form already. Prednisolones are specifically used when talking about lymphoma due to the potential side effects of dexamethasone. Dr.s chooses one over the other base on preference or what you are treating -- specific diseases have research to back the use of one--lymphoma does better with prednisolone. You will not see a fast improvement with just prednisolone or even if you added stronger chemo. It is a slow progress no matter what. Just using prednisolone you can see a good appetite, no change in diarrhea, no added weight gain. It merely suppress the cancer cells temporarily and helps them feel better. Even with other chemos, it is long term process with slow results---2-4 months to see improvement with the diarrhea in severe cases. They stay on the medicine long term and the doses can be alternated based on how each patient responds

His response to the steroid injection may be more indication that he does have lymphoma. Prednisone, a steroid, is commonly used in conjunction with a chemotherapeutic agent to treat lymphoma in cats. The steroid will decrease inflammation which may reduce his symptoms. Consider a consult with a veterinary oncologist to discuss testing for a definitive diagnosis after which treatment, if you choose, can begin.

IBD and GI lymphoma can look identical on lab work and ultrasound - the only way to distinguish the two for certain is to do an intestinal biopsy. Steroids can decrease the number of inflammatory cells and make diagnosis more difficult. Both can be difficult to manage, and each cat may need a different treatment plan. Often pain medications, nausea medications, anti-inflammatories, hypoallergenic diets, probiotics, antibiotics, etc are needed.

Poor Kitty! Since she is already 17 years old and she is having such a tough time with her inflammation in her GI tract, I think steroids will be the best choice for her. If her blood work looks okay now, then I think she can tolerate the steroids. Unfortunately, if you don't put her on steroids the lymphoma or IBD may continue to get worse. It is true the steroids will not CURE lymphoma, but it certainly give her a better quality of life right now. It could keep the IBD under control and eventually you may be able to decrease her steroid dose to a lower dose. The concerns of long term steroids are much lower since she is already geriatric. If she was 4 or 7 years old, then I would be much more worried with starting her on long term steroids at that time. At the age of 17, our goal is to give Kitty are good quality of life. If you want more options about the lymphoma and interested in seeing an oncologist, I would ask your vet for a referral for a oncology consult. I hope this helps!

Max is already on a high dose of prednisone and I doubt increasing the dose would improve his symptoms. Prognosis depends on the type and stage of lymphoma, but in general the median survival time with prednisone is about a month. I'm so sorry about Max's diagnosis.

Hi there! Thanks for using Petco Pet Education Center, formerly Petcoach! This is a common question I encounter as I only see cancer patients and lymphoma is very common in my practice. Prednisone is good for lymphoma though as you are noticing, lymphoma will eventually progress, as noted by peripheral lymph node enlargement. Normally, lymphoma will not cause clinical signs for some time until it enters more of the end stage. Lymphoma is not typically a painful disease and it is more of a debilitating disease. For this reason, what you will notice at the end is clinical signs such as lethargy, decreased appetite and Brandi just not being interested in the normal things that she enjoys. The median survival time of dogs with multicentric lymphoma just on prednisone is about 2 to 2 and 1/2 months. Usually I tell my clients that the time to consider humane euthanasia is when they are not doing 3 out of their 5 favorite things. Good luck with your girl!

Thanks for using Petco Pet Education Center, formerly Petcoach! I am sorry to hear that. Lymphoma is an aggressive disease in cats, especially when in the gastrointestinal system and in circulation. Usually even with chemotherapy you are looking at a prognosis of 2-6 months depending on the exact type of lymphoma. You could try prednisolone as a palliative treatment to make her feel better for the time being and perhaps extend her survival time for a few weeks. If she is already anemic, she may also require a blood transfusion making things a bit more complicated. If she is not doing well and you are not interested in pursuing therapy knowing the prognosis then euthanasia is a good option. Let me know if you have further questions regarding her disease. Sorry for the sad news!