My cat is still in pain. Can I give buprenorphine early or CBD?

I am not sure how you are able to tell that he hasn't slept for 24 hrs unless you are also up yourself the entire time. Chances are he has slept somewhat, but these are still concerning symptoms that he may be having an adverse reaction to the medicaiton or that a lower dose is needed for him. Also it is concerning if he hasn't gone potty. Male neutered cats can get urinary blockages which causes them to be very vocal, lethargic and strain to urinate. I would advise taking him to your local vet right away for an evaluation and potentially stopping his medication until he is deemed healthy enough to proceed with either this medicaiton or an alternative. I hope that Cucho is able to make a full and speedy recovery. Best wishes and take care.

This represents a pretty substantial overdose. Corbett got about 2.5 times more than the highest published dose for pain relief. However, it's thought that buprenorphine has a high index of safety, and even large overdoses don't usually cause serious effects. I'm assuming you gave it on the gums ("transmucousally") as that's how it's typically prescribed for pain relief at home in cats. Because of that method of administration, there's no way to remove the drug from his system by inducing vomiting. There is a reversal agent that is somewhat effective, but may have to be given in multiple doses due to the way buprenorphine works. The drug is naloxone, and your veterinarian should have this drug. Because the signs of overdose can be concerning (vocalization, ataxia, hypersalivation, decreased body temperature, and lethargy) my best recommendation would be for you to take Corbett back to your veterinarian for administration of this drug, so that the overdosage can be averted.

Buprenorphine can be given as often as every 6 hours, but it's typically prescribed to be given every 8 hours. It can be difficult to know for sure whether a cat's in pain, but I would look for signs like a relaxed posture, not hiding, interest in food and attention as signs that Kiki is comfortable. If you give it every 6 hours you can be pretty confident that it's doing it's job.

Have you been giving him the buprenorphine? This could be making him very lethargic. If he doesnt seem really painful, you may consider stopping the pain meds or giving him a half dose to see if they helps to perk him up a bit. But if he is continuing to be lethargic despite not being on pain medication then I believe he needs to follow up with your vet to ensure nothing else is wrong. I hope he starts to feel better!

With your cat's weight being 11 pounds, there is a dose range for Buprenorphine that fits into the amount you gave. He may be a little sleepier and I would not continue the double dose unless your vet recommends it. Keep an eye on him in case he is too sleepy, but he should be ok. Signs of a problem would be too sleepy, a slower breathing rate.

With pain relief medication the goal is to use as needed. So if you believe Roman is in pain or uncomfortable it is good to give him the medication, but you do not have to finish a course like with antibiotics. I would continue the buprenex as long as you feel that Roman is still in pain, and also the packaging label from the veterinarian who prescribed the pills should indicate how many days he believes Roman should take the pills. Bladder inflammation can take days to weeks to calm down so h may need the pills for longer. Thank you for using Petco Pet Education Center, formerly Petcoach!

Hello and thank you for contacting Petco Pet Education Center, formerly Petcoach. You can give Blackie maximum of 2 days with rest indoor and oral administration of buprenorphine. If it is only muscle or joint pain, he should be much better by Sunday. If there is no improvement in 2 days time, you should get Blackie seen at your local vets, possibly to x-ray the leg. Also, transmucosal buprenorphine lasts about 6-8 hrs in cats. You can increase the dose to 0.2ml 3 times a day.