My cat stopped eating, drinks a lot, and seems sad. What's wrong?

I doubt very much that the litter change had anything to do with the signs you are currently seeing in Misu. Lack of appetite and not drinking water are both serious problems that could be caused by pain, nausea, internal organ problems (like kidneys or liver), or intestinal issues. Unfortunately these are very vague signs and he will need some tests, like bloodwork, urinalysis, and possibly x-rays to determine what is going on, and how to treat it. I urge you to call again and make an urgent appointment, or take him on to see an emergency veterinarian tonight.

I am sorry to hear about Annabelle. If she is not eating and now not drinking these are definitely signs of concern that require evaluation by a veterinarian. In particular, if she is an overweight cat (it says on your information that she is 14 pounds) then she is at risk of developing a dangerous liver condition called hepatic lipidosis if she isn't eating. There are many possible underlying causes for her symptoms, including primary GI disease (such as inflammatory bowel disease, gastritis, stomach ulcer, gi tumors, gi infection, pancreatitis, cholangiohepatitis) or disease of the liver or kidney (either of these can cause increased thirst). The vet will want to do an examination and will likely recommend bloodwork and an x-ray to try to determine the cause of her symptoms. She may need to be prescribed an appetite stimulant, and may need fluid therapy if she is dehydrated.

Take Piper back into a vet immediately. It's extremely serious when a cat won't eat, and if they don't eat going on 72 hours, they will develop a fatty liver which is fatal without treatment. Please take her into a vet now. Best of luck.

I would take Crinkles into a vet immediately. It's actually quite serious when a cat won't eat, and if they go long enough without eating, they develop a fatty liver. A fatty liver is fatal without treatment. Anorexia is a very general sign of illness and it can be caused by things such as dental problems, systemic illness, infection, inflammation, or injury. Please take him into a vet now.

Thanks for using Petco Pet Education Center, formerly Petcoach! This is in fact a concerning sign in cats as inappetence can be observed with conditions such as pancreatitis, kidney disease (most likely chronic in nature), dietary indiscretion and diabetes, just to mention a few possibilities. Cats can develop serious illness when they stop eating. This is known as hepatic lipidosis which is directly related to anorexia. I recommend that if Nutmeg is not eating by tomorrow morning, to have her evaluated by your veterinarian for further assessment and treatment. General labwork and thoracic/abdominal imaging may be recommended for work-up. Treatment would be based on findings. Good luck! Hoping for a speedy recovery!

There are a number of things that could cause Newman to stop eating and drinking such as systemic illness, infection, inflammation, or injury. It's actually extremely serious when a cat won't eat, as they will develop a fatty liver if they don't eat going on 72 hours. A fatty liver is fatal without treatment. He needs to see a vet now. Please take him into an ER vet clinic; if there isn't one in your area, there will be a vet on call for emergencies. The information to reach that vet is found on a clinic's answering machine or website.

Poor Gizmo Hill! If she has not eaten in three days, this is a very serious problem - cats can develop a life-threatening illness called hepatic lipidosis from not eating for multiple days in a row, so it's very important to find out what is causing her to not eat and get her started on appropriate treatment right away. I would recommend taking her to the vet for an exam as soon as you are able to - she may need blood work and x-rays to help diagnose the problem so that she can be treated before things get worse.