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Pet Pharmacy/
Prescription Flea & Tick Medicine

Prescription Flea & Tick Medicine

Fun ON. Bugs OFF. $10 OFF $50+ flea & tick prevention orders with in-store pickup.

RX Flea & Tick for Dogs
RX Flea & Tick for Cats

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49 - 96 of 106 results

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Credelio Chewable Tablet for Dogs 25.1-50 lbs
(44) reviews
+ More Choices Available
Advantage Multi Topical Solution for Cats 5.1 to 9 lbs
(15) reviews
+ More Choices Available
Advantage Multi Topical Solution for Dogs 20.1 to 55 lbs
(46) reviews
+ More Choices Available
Simparica Trio for Dogs 2.8-5.5 lbs.
(15) reviews

+ More Choices Available
Advantage Multi Topical Solution for Dogs 55.1 to 88 lbs
(46) reviews
+ More Choices Available
Revolution Topical Solution for Dogs 10.1-20 lbs
(111) reviews
Bravecto Plus Topical Solution for Cats Greater Than 13.8-27.5 lbs
(8) reviews
$55.99
Sentinel Flavor Tabs for Dogs 51 to 100 lbs
(184) reviews
$76.99

+ More Choices Available
Revolution Topical Solution for Dogs 20.1-40 lbs
(64) reviews
Sentinel Flavor Tabs for Dogs 2 to 10 lbs
(68) reviews
$51.99
Iverhart Plus Chewable Tablets for Dogs 1 to 25 lbs.
(24) reviews
$28.26
Iverhart Max Soft Chews for Dogs 50 to 100 lbs
(24) reviews
$59.55
+ More Choices Available
Trifexis Chewable Tablets for Dogs 5 to 10 lbs
(53) reviews
Interceptor Flavor Tabs for Dogs 11 to 25 lbs and Cats 1.5 to 6 lbs
(22) reviews
$56.49
+ More Choices Available
Revolution Topical Solution for Cats 15.1-22 lbs
(51) reviews
+ More Choices Available
Revolution Plus Topical Solution 2.8-5.5 lbs. Cat
(14) reviews
Tri-Heart Plus Chewable Tablets for Dogs 26 to 50 lbs.
(89) reviews
$38.99
+ More Choices Available
Advantage Multi Topical Solution for Dogs 3 to 9 lbs
(26) reviews
Sentinel Spectrum Chewables for Dogs 25.1 to 50 lbs.
(40) reviews
$67.99
Iverhart Plus Chewable Tablets for Dogs 51-100 lbs
(24) reviews
$49.09
Interceptor Flavor Tabs for Dogs 2 to 10 lbs.
(12) reviews
$53.99
Comfortis Chewable Tablets for Dogs 40.1 to 60 lbs
(12) reviews
$141.19
+ More Choices Available
Revolution Topical Solution for Dogs 85-130 lbs
(29) reviews
+ More Choices Available
Simparica Chewable for Dogs 2.8-5.5 lbs.
(1) reviews
Sentinel Spectrum Chewables for Dogs 2 to 8 lbs.
(16) reviews
$54.99
+ More Choices Available
Revolution Topical Solution for Puppies and Kittens up to 5lbs
(22) reviews
Bravecto 1-Month Chews for Dogs 9.9-22lbs
(16) reviews
$27.99
+ More Choices Available
Simparica Chewable for Dogs 5.6-11 lbs.
(27) reviews
Bravecto Topical Solution for Dogs 9.9-22 lbs
(18) reviews
$68.99
Sentinel Spectrum Chewables for Dogs 8.1 to 25 lbs.
(51) reviews
$56.99
Iverhart Max Soft Chews for Dogs 12 to 25 lbs
(4) reviews
$41.17
Bravecto 1-Month Chews for Dogs 4.4-9.9lbs
(7) reviews
$27.99
+ More Choices Available
Advantage Multi Topical Solution for Dogs 88.1 to 110 lbs
(18) reviews
Bravecto Topical Solution for Dogs 22-44 lbs
(6) reviews
$69.99
+ More Choices Available
Interceptor Plus Chewables for Dogs 2 to 8 lbs.
(38) reviews
Interceptor Flavor Tabs for Dogs 51 to 100 lbs and Cats 12 to 25 lbs
(25) reviews
$78.49
Interceptor Flavor Tabs for Dogs 26 to 50 lbs and Cats 6.1 to 12 lbs
(16) reviews
$67.99
Bravecto Topical Solution for Cats 13.8-27.5 lbs
(25) reviews
$77.99
+ More Choices Available
Credelio Chewable Tablet for Dogs 4.4-6 lbs
(12) reviews
Advantage Multi Topical Solution for Cats 2 to 5 lbs
(8) reviews
$80.49

Iverhart Max Soft Chews for Dogs 25 to 50 lbs
(10) reviews
$50.45
Iverhart Max Soft Chews for Dogs 6 to 12 lbs.
(4) reviews
$41.17
+ More Choices Available
Simparica Chewable for Dogs 88.1-132 lbs.
(11) reviews
MilbeGuard Flavor Tabs 26 to 50 lb dog
(2) reviews
$30.99 was $35.39
Bravecto Topical Solution for Dogs 4.4-9.9 lbs
(3) reviews
$67.99
Bravecto Topical Solution for Dogs 44-88 lbs
(15) reviews
$69.99
MilbeGuard Flavor Tabs 51 to 100 lb dog
(3) reviews
$38.99 was $45.31
Bravecto Plus Topical Solution for Cats 2.6-6.2 lbs
(1) reviews
$54.99

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Related Articles & Questions

New Pet
Protect Your Pet: Flea & Tick Control Solutions for Dogs & Cats
Learn how to remove flea and ticks. Petco has flea and tick removal services for dogs and cats. Get fleas and ticks removed at your neighborhood Petco.
Updated on July 28th, 2026
Health & Wellness
How Long After Pest Control Is It Safe for Pets?
You may have heard that flea and tick prevention are crucial for dogs and cats, but do you know why? Petco is sharing why and how to prioritize pest prevention for your pet.
Updated on June 19th, 2026
Health & Wellness
Flea & Tick Prevention: Oral vs. Topical - What's Best for Your Pet?
Most pet parents are familiar with topical or oral flea and tick preventives. So which is better for your pet—topical or oral?
Updated on October 23rd, 2025
Health & Wellness
Flea Infestation in Dogs & Cats: Symptoms, Treatment & Prevention
Read more about the different types of flea treatments and how they work to help eliminate fleas from your pet for their safety and happiness.
Updated on June 19th, 2026
Health & Wellness
Can You Switch Flea and Tick Medicine?
At some point in your pet’s life, you might want to switch from one flea and tick medication to another. So, how do you make the transition?
Updated on June 19th, 2026
Health & Wellness
Can Petco vets prescribe flea and tick medicine for my dog or cat?
Petco carries a variety of flea and tick medication over the counter. You can only get a prescription product from a veterinarian if they have examined Bruno. Petco does offer vaccine clinics but you would need to check with the specific services individually. Here is a link: https://www.vetcoclinics.com/ I hope this helps and please feel free to post any additional questions.
Updated on September 24th, 2025
Health & Wellness
What are the best prescription flea and tick chews for my dogs?
The easiest way to do so is to go to your veterinarian and either buy the chews from him or get a prescription from your vet and get them over the internet. I am assuming you are looking to buy either Bravecto, Simparica or Nexgard. These are prescription only.
Updated on September 24th, 2025
Vet Q & A
Where can I get affordable Nexgard for my dog's prescription?
You can find this product at any of the online veterinary pharmacies. In order to find the best value I would recommend going on goodrx.com. On this website you will be able to type in the medication and dose and it will provide you with coupon codes and the location of where you need to obtain the product. Regardless of what site you use you will still need to obtain a prescription from your veterinarian. I always caution my clients when they are planning to purchase these types of products from pharmacies of unknown origin as we cannot be certain how the drugs are being stored and what source they are obtaining the drugs from. Do your due diligence before deciding on which place to use. I have had relatively good experiences with Valley Vet Supply.
Updated on September 24th, 2025
Vet Q & A
How to get prescription flea chews for my dog without a vet?
Unfortunately we cannot provide any prescription through this website as legally we would need to physically assess your Oliver to be able to prescribe any medication. Unfortunately the only way to have an OTC flea treatment is to buy one at the local pet shop if a local vet is not available.
Updated on September 24th, 2025
Vet Q & A
Should I buy flea, tick, heartworm medicine online or from my vet?
Hi and thanks for using Petco Pet Education Center, formerly Petcoach! Good question! In general it is best to purchase these medications from your veterinarian. When purchased through a veterinarian the company will most often guarantee the effectiveness. This is usually not the case with products bought online or over the counter. When sold through a veterinarian the company that manufactures the product will stand behind the product and often pay for medical treatment should the product not work for some reason. The veterinarian also knows how to properly store the product so that it does not get damaged or becomes ineffective. Finally, sometimes over the counter products or products sold online can be counterfeit or even dangerous to use. Your veterinarian also knows what particular products tend to be most effective for your location.
Updated on September 24th, 2025

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