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100% Satisfaction Guarantee on Protection
Protection from the Start
Approved for dogs as young as 8 weeks old, weighing at least 2.8 lbs.
#1 Vet Prescribed Combo Preventative1
How Simparica Trio Simplifies Protection
With three proven ingredients designed for defense, a single monthly
chew does the job of two or three preventatives.
Ticks
Kills 6 types of ticks,
including the deer tick that
may carry Lyme disease.*
Heartworm Disease
1 dose provided 100%
protection against
heartworm disease.†
Fleas
Prevents flea infestation by
killing fleas before they can
even lay eggs.‡
Intestinal Worms
Treats and controls
roundworms and
hookworms, and prevents
tapeworm by killing fleas.§
Shop Protection for All Sizes
Safe and effective for dogs and puppies 8 weeks and older, weighing at least 2.8 lbs.
See the Simparica Trio Difference
Simparica Trio was the first combo preventative to block Lyme infections‖ and remains
a trusted choice for comprehensive protection.
Benefit*
Simparica Trio
Heartguard PLUS
Nexgard
Nexgard PLUS
Bravecto
Credelio Quattro
Kills 6 Types
of Ticks
5 Types
5 Types
5 Types
5 Types
Prevents Lyme
Infections*
Kills Fleas
Before They Can
Lay Eggs
Prevents
Heartworm
Disease
Treats
Roundworms
& Hookworms
Prevents
Tapeworms**
Get the Chew That's Protected
15 Million Dogs, and Counting2
Ready to enhance your dog's parasite protection with Simparica Trio? Get triple protection for your pup in a tasty, once-a-month chew, today!
Important Safety Information:
Use with caution in dogs with a history of seizures. Simparica Trio contains sarolaner, a member of the isoxazoline class which has been associated with neurologic adverse reactions including tremors, ataxia, and seizures in dogs with or without a history of neurologic disorders. The safe use of Simparica Trio has not been evaluated in breeding, pregnant, or lactating dogs. The most frequently reported adverse reactions in clinical trials were vomiting and diarrhea. See full Prescribing Information at SimparicaTrioPI.com.
*For the treatment and control of the Gulf Coast Tick ( Amblyomma maculatum ), Deer Tick ( Ixodes scapularis ), American Dog Tick ( Dermacentor variabilis ), Lone Star Tick ( Amblyomma americanum ), Brown Dog Tick ( Rhipicephalus sanguineus ), and Asian Longhorn Tick ( Haemaphysalis longicornis ). †Studies to support FDA approval showed that 1 dose provided 100% protection against heartworm disease. ‡Simparica Trio starts killing fleas within 4 hours. §For the treatment of roundworm (immature adult and adult Toxocara canis and adult Toxascaris leonina ) and treatment of hookworm (L4, immature adult, and adult Ancylostoma caninum and adult Uncinaria stenocephala ) infections. Indicated for the prevention of Dipylidium caninum (tapeworm) infections, by killing fleas. ‖By killing deer ticks.
References:
1. Kynetec PetTrack US FTH National Data January 10, 2025.
2. Simparica Trio - 15M Dogs and Counting, PetTrak Kynetec Veterinary Channel Review Q4, 2024.