Thank you for contacting Drs. Foster & Smith with your question. There are no known drug interactions between Sentinel Spectrum and Seresto. The products are safe to use together. But as with any product, we always recommend discussing with your veterinarian whether this combination is appropriate for your particular pet. We hope this information is helpful. Thanks again for contacting us. Best regards, Veterinary Services Drs. Foster & Smith

Thank you for contacting Doctors Foster and Smith with your question. Sentinel Spectrum and Frontline Plus contain different ingredients that work in different ways. As long as your dog has no drug sensitivities to any of the ingredients, these two products can be used together. The Sentinel Spectrum contains an insect development inhibitor, which prevents the immature stages of fleas from developing into adults. It does not kill adult fleas. That is where the topical product becomes important. In this case, Frontline Plus would kill the adults, as well as the larvae and eggs. Sentinel Spectrum also is a heartworm preventive and also treats and controls several types of intestinal parasites. We always recommend discussing products with your veterinarian before administering them to your pet. Your veterinarian can assist you in choosing the best products for your pet’s specific needs and also help avoid potential problems as well. We hope this information is helpful. Thanks again for contacting us. Sincerely, Veterinary Services Drs. Foster & Smith

My vet did let me give the regular Sentinal with Nexgard at the same time. Nexgard was very expensive though and my husky got sick two days after taking it but it probably was not related. We are thinking about trying Trifexis but that doesnt do ticks either.

Thank you for your question. Sentinel Spectrum also contains praziquantel for control of tapeworms.