Neo-Predef with Tetracaine is applied topically. Always follow the dosage instructions provided by your veterinarian. If you have difficulty applying the medication, contact your veterinarian. The ear or area of skin should be thoroughly cleaned and dried before treatment. For the ear, remove any debris, crusty material, etc., with a suitable nonirritating ear cleaning solution. For the skin, use a skin cleansing solution to clean the lesion and adjacent area. Clip any excessive hair from the ear or treatment area as directed by your veterinarian. Apply the powder by compressing the sides of the container with short, sharp squeezes. Do not let the tip of the container come in contact with anything moist, including a moist lesion or skin. Prevent ingestion of the medication. If ingested at high doses or for extended periods, corticosteroids can cause premature birth especially toward the end of pregnancy.