The 22oz box says it contains an 8 week supply for a 50lb dog, and that the box has about 92 biscuits. It also says you should give a 50lb dog 1.5 biscuits per day. Additionally it recommends 2 biscuits per day for a dog 51-80lbs in weight. I give my 47lb dog only 1 per day, and not every single day - probably 4 per week. He does not really like the flavor, so I give a treat he likes more first and then give the grass saver biscuit, which he will then eat.