Excellent product for arthritic horses; does not affect all equally. However, noticeable improvements in both my horses. In one older arthritic gelding, improvement in mobility was noted next day. He is dosed weekly for maintenance. The other, a young Draft mare, who showed signs of "growing pains" has also benefitted from the loading doses and subsequent monthly doses. This product is one of the only that actual quickly shows results after loading dosages. Nevertheless. there are some horses that show no or minimal signs of improvement. The results are a case by case outcome.